There are both large and small ADC molecules. A variety of biological analysis methods and platforms are needed to analyze the diversity of ADCs. Conventional LC-MS/MS small-molecule assays are often used to analyze uncoupled payloads and DAR distributions over time, while ligand binding assays (LBA) and LC-MS/MS can also be used to analyze total antibodies (TAb) and total ADCs. The choice of analysis platform depends on the availability of key reagents, the required analytical See More sensitivity, and the different problems that need to be addressed at various stages of drug development. In this article, the classical LBA and LC-MS/MS methods for quantitative analysis of ADC components are briefly introduced. Url:https://adc.bocsci.com/services/dar-and-drug-distribution-analysis.html
Drug to Antibody Ratio - BOC Sciences
The Drug to Antibody Ratio (DAR) is a measure used in the field of antibody drug conjugate (ADC), which are a type of targeted cancer therapy. The DAR refers to the average number of drug molecules attached to each antibody molecule in an ADC.
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