Reproductive Pharmacology Quiz focuses on reproductive drugs, namely the oestrogens, progestins and androgens. Selective modulators and therapies linked to these hormones will be discussed. Matt2425 published on April 14, 2013 Stacked 1/5 Which of the following is NOT a side effect of the hormone oestrogen? Acne Thromboembolism Osteoporosis Migraine 2/5 Which of the following drugs is used to treat infertility? Tamoxifen Ethinyl estradiol Clomiphene Raloxifene 3/5 What is the mechanism of action of sildenafil? It is a vasodilator, increasing bloodflow to the corpus cavernosum. It is a L-type calcium channel blocker, reducing influx of calcium from smooth muscle stores. It is an alpha-1 AR agonist, dilating blood vessels to increase vascular flow to corpus cavernosum It inhibits phosphodiesterase 5, preventing conversion of cGMP to 5' GMP, lowering iCa stores, relaxing the smooth muscle. 4/5 What is the principle of using estrogen and progestin as contraceptives? Estrogen binds to the ER receptor in the anterior pituitary, inhibiting release of FSH. Progestin also inhibits the ER receptor of the anterior pituitary. Estrogen binds to the ER receptor in the anterior pituitary, inhibiting release of FSH. Progestin also reduces frequency of GnRH release from the hypothala... Estrogen binds to the ER receptor in the anterior pituitary, inhibiting release of FSH. Progestin reduces frequency of LH release from the anterior pituitary. Estrogen reduces frequency of LH release from the anterior pituitary. Progestin inhibits FSH secretion from the hypothalamus. 5/5 Which of the following are examples of female long term contraceptives? Norethindrone Norgestrel Levonorgestral Finasteride
